Biomaterial Database

[Accumulation of methylated purines in the liver and large intestine DNA of rats following repeated administrations of 1,2-dimethylhydrazine]. 1980

A Ia Likhachev, and A S Petrov

Experiments on rats given weekly injections of the intestinal carcinogen 1,2-dimethylhydrazine (DMH) have shown that liver and colon DNA accumulated 7-methylguanine and some methylated adducts of adenine. In addition, DNA of liver tissues and crypt bottom cells accumulated O6-methylguanine. The conclusion is drawn on the role of its persistence in DNA of stem enterocytes in the initiation of colonic carcinogenesis. The mechanism of liver tissue resistance to the carcinogenic effect of DMH is discussed.

UI	MeSH Term	Description	Entries
D007420	Intestine, Large	A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.	Large Intestine
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D008745	Methylation	Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)	Methylations
D008763	Methylhydrazines	Hydrazines substituted by one or more methyl groups in any position.
D004127	Dimethylhydrazines	Hydrazines substituted with two methyl groups in any position.	Dimethylhydrazine
D004247	DNA	A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).	DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D006147	Guanine
D000225	Adenine	A purine base and a fundamental unit of ADENINE NUCLEOTIDES.	Vitamin B 4,4, Vitamin B,B 4, Vitamin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia