[Growth kinetics statistical analysis of chemo-induced carcinomas and sarcomas in mice (author's transl)]. 1980

M Denechaud, and D Ducassou

An experimental model allowing comparative studies of growth kinetics of autochtonous tumours with differentiated histology was investigated. Epithelial and mesenchymal tumours were chemically induced in mice. The distribution of parameters defining the growth of these two tumour types was first studied. Then, the correlations were calculated between the three following paired parameters: doubling times, defined during the whole growth period, latent tumoral period and survival times. The results confirmed the initial hypothesis that tumour growth kinetics were related to histological character. The study showed that there was a significant difference between growth rates, maximum sizes and survival delays respectively presented by sarcomas and carcinomas. Owing to the slow growth rate of these autochtonous tumours, this experimental model is a very interesting tool to investigate various therapeutic protocols for human beings.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D009374 Neoplasms, Experimental Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D002277 Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." Carcinoma, Anaplastic,Carcinoma, Spindle-Cell,Carcinoma, Undifferentiated,Carcinomatosis,Epithelial Neoplasms, Malignant,Epithelioma,Epithelial Tumors, Malignant,Malignant Epithelial Neoplasms,Neoplasms, Malignant Epithelial,Anaplastic Carcinoma,Anaplastic Carcinomas,Carcinoma, Spindle Cell,Carcinomas,Carcinomatoses,Epithelial Neoplasm, Malignant,Epithelial Tumor, Malignant,Epitheliomas,Malignant Epithelial Neoplasm,Malignant Epithelial Tumor,Malignant Epithelial Tumors,Neoplasm, Malignant Epithelial,Spindle-Cell Carcinoma,Spindle-Cell Carcinomas,Tumor, Malignant Epithelial,Undifferentiated Carcinoma,Undifferentiated Carcinomas
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012513 Sarcoma, Experimental Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. EHS Tumor,Sarcoma, Engelbreth-Holm-Swarm,Sarcoma, Jensen,Experimental Sarcoma,Experimental Sarcomas,Sarcomas, Experimental,Engelbreth-Holm-Swarm Sarcoma,Jensen Sarcoma,Sarcoma, Engelbreth Holm Swarm,Tumor, EHS
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

M Denechaud, and D Ducassou
January 1974, Verhandlungen der Deutschen Gesellschaft fur Pathologie,
M Denechaud, and D Ducassou
January 1980, Zentralblatt fur Gynakologie,
M Denechaud, and D Ducassou
January 1979, La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
M Denechaud, and D Ducassou
January 1983, Bulletin du cancer,
M Denechaud, and D Ducassou
December 1978, Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris,
M Denechaud, and D Ducassou
July 1978, Nihon Jibiinkoka Gakkai kaiho,
M Denechaud, and D Ducassou
April 1978, Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
M Denechaud, and D Ducassou
February 1977, La Radiologia medica,
M Denechaud, and D Ducassou
January 1975, Archiv fur Geschwulstforschung,
M Denechaud, and D Ducassou
December 1976, Casopis lekaru ceskych,
Copied contents to your clipboard!