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A serial study on 32 patients with bone metastases following cancer of the breast or prostate was performed over three years. Up to ten sets of images (average of four) per patient were obtained during this period using 99Tcm methylene diphosphonate as the radiopharmaceutical. Ninety-three paired serial images of individual lesions were qualitatively assessed for change by three physicians in nuclear medicine and the results were compared with the quantitative results from computer analysis. The reproducibility of the quantitative approach was determined by the analysis of 20 paired lesions by three physicists. It was found that quantitative changes in uptake of less than 20% between images were generally not detected by the medical observers; a change of 41% had only a 95% probability of being identified as change by the physicians. Although much more reproducible in determining changes in individual lesions, the quantitative approach was found to be inferior to the qualitative assessment of overall change in the majority of cases which involve multiple lesions. The basic assumption that uptake varies proportionally with progression of the bone lesion is discussed an is considered in some instances to be untenable. The conclusion is drawn that the determination of progression from changes of uptake in longstanding lesions is uncertain and is subsidiary in importance to the detection of new lesions.
B R Condon, and
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N W Garvie, and
D M Ackery, and
J Fleming, and
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B A Goddard
October 2016,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
B R Condon, and
R Buchanan, and
N W Garvie, and
D M Ackery, and
J Fleming, and
D Taylor, and
D Hawkes, and
B A Goddard
January 1982,
European journal of nuclear medicine,
B R Condon, and
R Buchanan, and
N W Garvie, and
D M Ackery, and
J Fleming, and
D Taylor, and
D Hawkes, and
B A Goddard
January 2010,
Current topics in medicinal chemistry,
B R Condon, and
R Buchanan, and
N W Garvie, and
D M Ackery, and
J Fleming, and
D Taylor, and
D Hawkes, and
B A Goddard
December 2021,
Der Urologe. Ausg. A,
B R Condon, and
R Buchanan, and
N W Garvie, and
D M Ackery, and
J Fleming, and
D Taylor, and
D Hawkes, and
B A Goddard
August 2012,
The Prostate,
B R Condon, and
R Buchanan, and
N W Garvie, and
D M Ackery, and
J Fleming, and
D Taylor, and
D Hawkes, and
B A Goddard
October 2012,
Radiation oncology (London, England),
B R Condon, and
R Buchanan, and
N W Garvie, and
D M Ackery, and
J Fleming, and
D Taylor, and
D Hawkes, and
B A Goddard
April 1980,
Radiology,
B R Condon, and
R Buchanan, and
N W Garvie, and
D M Ackery, and
J Fleming, and
D Taylor, and
D Hawkes, and
B A Goddard
July 2013,
Seminars in nuclear medicine,
B R Condon, and
R Buchanan, and
N W Garvie, and
D M Ackery, and
J Fleming, and
D Taylor, and
D Hawkes, and
B A Goddard
November 1987,
Cancer,
B R Condon, and
R Buchanan, and
N W Garvie, and
D M Ackery, and
J Fleming, and
D Taylor, and
D Hawkes, and
B A Goddard
May 1967,
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
