Biomaterial Database

Cerebrospinal fluid pressure changes during the induction phase of anaesthesia. 1980

M M Nayak, and I M Bali, and H Singh, and Y K Batra

Cerebrospinal fluid pressure (CSFP) by lumbar puncture, systemic blood pressure (BP) and pulse rate (PR) were measured for 15 minutes during the induction phase of general anaesthesia in seven groups of six healthy female patients each. Intravenous drugs, thiopentopne 5 mg . kg-1, alfathesin 50 microliters . kg-1 and diazepam 0.5 mg . kg-1 given in 10 to 20 seconds caused a fall of CSFP and BP, whereas ketamine 2 mg . kg-1 and a three-minute induction with halothane three per cent, trichloroethylene one per cent, or methoxyflurane 0.75 per cent caused a sharp highly significant but short-lived rise of CSFP. Unlike ketamine, trichlorethylene and methoxyflurane, halothane caused a simultaneous significant fall of BP. To rule out apprehension as the cause of the rise of CSFP with inhalation agents a second challenge was given with similar concentrations of the vapours while patients were asleep. These still produced a sharp and significant rise of CSFP.

UI	MeSH Term	Description	Entries
D007427	Intracranial Pressure	Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.	Intracerebral Pressure,Subarachnoid Pressure,Intracerebral Pressures,Intracranial Pressures,Pressure, Intracerebral,Pressure, Intracranial,Pressure, Subarachnoid,Pressures, Intracerebral,Pressures, Intracranial,Pressures, Subarachnoid,Subarachnoid Pressures
D007649	Ketamine	A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.	2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone,CI-581,Calipsol,Calypsol,Kalipsol,Ketalar,Ketamine Hydrochloride,Ketanest,Ketaset,CI 581,CI581
D011674	Pulse	The rhythmical expansion and contraction of an ARTERY produced by waves of pressure caused by the ejection of BLOOD from the left ventricle of the HEART as it contracts.	Pulses
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D006221	Halothane	A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)	1,1,1-Trifluoro-2-Chloro-2-Bromoethane,Fluothane,Ftorotan,Narcotan
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000758	Anesthesia	A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
D000769	Anesthesia, Inhalation	Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.	Insufflation Anesthesia,Anesthesia, Insufflation,Inhalation Anesthesia
D000771	Anesthesia, Intravenous	Process of administering an anesthetic through injection directly into the bloodstream.	Anesthesias, Intravenous,Intravenous Anesthesia,Intravenous Anesthesias