Biomaterial Database

Enhancement of mammary carcinogenesis by a high-fat diet in Fischer, Long-Evans, and Sprague-Dawley rats. 1981

P C Chan, and T L Dao

The relationship between dietary fat and mammary carcinogenesis was examined by feeding a high-fat or a low-fat purified diet, differing only in fat and carbohydrate content, to Fischer, Long-Evans, and Sprague-Dawley rats. An additional group of rats from each strain was fed a nonpurified laboratory diet for comparison. The rats were given an i.v. dose of N-nitrosomethylurea (50 mg/kg body weight) at 50 days of age. The results showed that (a) a high-fat purified diet significantly enhanced mammary carcinogenesis; (b) a nonpurified laboratory diet retarded mammary carcinogenesis compared to a low-fat purified diet; (c) rats on three different diets had a similar body weight gain; (d) the susceptibility of N-nitrosomethylurea-induced mammary carcinogenesis in the three strains of rats was in the order of Sprague-Dawley > Fischer > Long-Evans; and (e) Fischer rats appeared to be better suited for further systematic studies of dietary fat and mammary carcinogenesis.

UI	MeSH Term	Description	Entries
D008325	Mammary Neoplasms, Experimental	Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.	Experimental Mammary Neoplasms,Neoplasms, Experimental Mammary,Experimental Mammary Neoplasm,Mammary Neoplasm, Experimental,Neoplasm, Experimental Mammary
D008770	Methylnitrosourea	A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.	Nitrosomethylurea,N-Methyl-N-nitrosourea,NSC-23909,N Methyl N nitrosourea,NSC 23909,NSC23909
D004041	Dietary Fats	Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.	Fats, Dietary,Dietary Fat,Fat, Dietary
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus