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1. Sixteen neurosurgical patients received (oral) beta-adrenoreceptor-blocking agents (beta-receptor blockers) for 3-22 days. 2. Lipophilic beta-receptor blockers (propranolol) and metoprolol appeared in cerebrospinal fluid at concentrations similar to the free drug plasma concentration. 3. Cerebrospinal fluid concentrations of beta-receptor blockers were poor predictors of brain concentrations. 4. Both lipophilic beta-receptor blockers appeared in high concentrations in the brain: the brain/plasma ratio was approximately 15:1. 5. Hydrophilic atenolol appeared at low concentrations in brain tissue (about 20 times lower than the lipophilic beta-receptor blockers): the brain/plasma ratio was approximately 0.1:1. 6. Central nervous system-related side effects associated mainly with lipophilic beta-receptor blockers possibly result from high brain tissue concentrations.
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
July 1993,
East African medical journal,
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
December 1978,
Clinical science and molecular medicine. Supplement,
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
January 1977,
Contributions to nephrology,
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
November 1969,
European journal of pharmacology,
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
October 2001,
Current eye research,
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
November 1972,
Archives internationales de pharmacodynamie et de therapie,
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
January 1980,
Brain research,
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
August 1979,
The Medical journal of Australia,
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
January 1981,
Dermatologica,
J M Cruickshank, and
G Neil-Dwyer, and
M M Cameron, and
J McAinsh
January 1985,
Journal of cardiovascular pharmacology,
