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The generation of somatomedin activity by isolated perfused livers was examined in protein-malnourished (4% casein diet) and well-nourished (controls, 20% casein diet) rats. There was significantly less somatomedin activity (measured by the porcine costal cartilage bioassay), after perfusion for 2 h, in the perfusates from the livers of malnourished rats both in hormone-free perfusates and perfusates containing hormones (10 microgram GH/ml, 1000 microunits insulin/ml or a combination of the two). A reduction in the somatomedin activity generated by the liver may be the mechanism responsible for the low serum level of somatomedin (in spite of raised or normal levels of growth hormone) in human or experimental protein malnutrition.
B Shapiro, and
K Waligora, and
B L Pimstone
December 1974,
The Journal of endocrinology,
B Shapiro, and
K Waligora, and
B L Pimstone
January 1975,
Advances in metabolic disorders,
B Shapiro, and
K Waligora, and
B L Pimstone
August 1989,
Metabolism: clinical and experimental,
B Shapiro, and
K Waligora, and
B L Pimstone
June 1996,
Danish medical bulletin,
B Shapiro, and
K Waligora, and
B L Pimstone
December 1973,
Diabetologia,
B Shapiro, and
K Waligora, and
B L Pimstone
March 1978,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
B Shapiro, and
K Waligora, and
B L Pimstone
November 1982,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
B Shapiro, and
K Waligora, and
B L Pimstone
January 1982,
Experientia,
B Shapiro, and
K Waligora, and
B L Pimstone
March 1976,
Endocrinology,
B Shapiro, and
K Waligora, and
B L Pimstone
May 1968,
Diabetes,
