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The toxicity of the original drug bonaphthon was studied in pregnant and nonpregnant mice and rats given the drug orally and intraperitoneally. In a dose of 100 mg/kg bonaphthon had no toxic effect on pregnant rats after 4-time administration per os, while in a single dose of 400 mg/kg the drug elicited side effects such as congestion phenomena and inconsistent dystrophic changes in the parenchymal organs. Toxic effects in the liver were most pronounced when the drug was administered in the earlier periods of pregnancy.
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