[Effect of central cholinolytics on conditioned reflex activity, pancreatic secretion and water diuresis]. 1980

I V Sergeeva, and O G Onisko, and E K Kuznetsova

During administration of amizil (0.3-0.6 mg/kg) and metamizil (0.1 mg/kg) there is a decrease in pancreatic secretion after ingestion of 100 g of meat, drinking of 600 ml of an aqueous-lactic mixture and irrigation of the duodenal mucosa with hydrochloric acid solution. Pancreatic secretion was completely suppressed in response to sham feeding. The time course of water-salt metabolism was disturbed: urination decreased during the first experimental hour. The cholinolytics did not produce such an effect on administration of the aqueous-lactic mixture directly into the stomach, avoiding the drinking. Research into the higher nervous activity has shown that even in a dose of 0.05 mg/kg amizil decreased the magnitude of conditioned and unconditioned salivation reflexes.

UI MeSH Term Description Entries
D010179 Pancreas A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D010276 Parasympatholytics Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. Antispasmodic,Antispasmodic Agent,Antispasmodic Drug,Antispasmodics,Parasympathetic-Blocking Agent,Parasympathetic-Blocking Agents,Parasympatholytic,Parasympatholytic Agent,Parasympatholytic Drug,Spasmolytic,Spasmolytics,Antispasmodic Agents,Antispasmodic Drugs,Antispasmodic Effect,Antispasmodic Effects,Parasympatholytic Agents,Parasympatholytic Drugs,Parasympatholytic Effect,Parasympatholytic Effects,Agent, Antispasmodic,Agent, Parasympathetic-Blocking,Agent, Parasympatholytic,Agents, Antispasmodic,Agents, Parasympathetic-Blocking,Agents, Parasympatholytic,Drug, Antispasmodic,Drug, Parasympatholytic,Drugs, Antispasmodic,Drugs, Parasympatholytic,Effect, Antispasmodic,Effect, Parasympatholytic,Effects, Antispasmodic,Effects, Parasympatholytic,Parasympathetic Blocking Agent,Parasympathetic Blocking Agents
D011950 Receptors, Cholinergic Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology. ACh Receptor,Acetylcholine Receptor,Acetylcholine Receptors,Cholinergic Receptor,Cholinergic Receptors,Cholinoceptive Sites,Cholinoceptor,Cholinoceptors,Receptors, Acetylcholine,ACh Receptors,Receptors, ACh,Receptor, ACh,Receptor, Acetylcholine,Receptor, Cholinergic,Sites, Cholinoceptive
D003214 Conditioning, Classical Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus. Reflex, Conditioned,Classical Conditioning,Classical Conditionings,Conditioned Reflex,Conditionings, Classical
D003864 Depression, Chemical The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical. Chemical Depression,Chemical Depressions,Depressions, Chemical
D004231 Diuresis An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Diureses
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006613 Higher Nervous Activity A term used in Eastern European research literature on brain and behavior physiology for cortical functions. It refers to the highest level of integrative function of the brain, centered in the CEREBRAL CORTEX, regulating language, thought, and behavior via sensory, motor, and cognitive processes. Activities, Higher Nervous,Activity, Higher Nervous,Higher Nervous Activities,Nervous Activities, Higher,Nervous Activity, Higher
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

I V Sergeeva, and O G Onisko, and E K Kuznetsova
January 1971, Farmakologiia i toksikologiia,
I V Sergeeva, and O G Onisko, and E K Kuznetsova
January 1966, Farmakologiia i toksikologiia,
I V Sergeeva, and O G Onisko, and E K Kuznetsova
January 1961, Farmakologiia i toksikologiia,
I V Sergeeva, and O G Onisko, and E K Kuznetsova
January 1957, Farmakologiia i toksikologiia,
I V Sergeeva, and O G Onisko, and E K Kuznetsova
January 1962, Activitas nervosa superior,
I V Sergeeva, and O G Onisko, and E K Kuznetsova
January 1961, Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova,
I V Sergeeva, and O G Onisko, and E K Kuznetsova
May 1960, Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
I V Sergeeva, and O G Onisko, and E K Kuznetsova
January 1969, Farmakologiia i toksikologiia,
I V Sergeeva, and O G Onisko, and E K Kuznetsova
January 1959, Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
Copied contents to your clipboard!