Biomaterial Database

[Ultrastructural-morphometric studies on the rat liver in the postnatal period. 1. Changes in the extrahepatocyte volume, the hepatocyte nuclei the cytoplasm and and the nucleus-cytoplasm ratio]. 1980

U Specht, and H David

Quantitative changes in the volume densities of extrahepatocyte spaces, nuclei of hepatocytes, cytoplasm and of the nucleus-cytoplasm-ratio were studied in male Wistar-rats aged 0 (birth), 1, 2, 3, 4, 5, 6, 7, 14, 21, 28 days and 2, 3, 4, 5 and 6 months. The ratio of hepatocyte/nonhepatocyte fractions is 40.3 : 59.7 at birth and it increases to 86.6 : 13.4 by the 6th month. We observed 2 phases of proliferations of hepatocytes in the first 4 days, while the single volume of hepatocytes reaches lower levels. After the 4th day the single volume of hepatocytes increases because of the augmentation of volume density of cytoplasm. According to these changes the nucleus-cytoplasm-ratio will be reduced to 0.077 by the 5th month.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D002467	Cell Nucleus	Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	Cell Nuclei,Nuclei, Cell,Nucleus, Cell
D003593	Cytoplasm	The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)	Protoplasm,Cytoplasms,Protoplasms
D005110	Extracellular Space	Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.	Intercellular Space,Extracellular Spaces,Intercellular Spaces,Space, Extracellular,Space, Intercellular,Spaces, Extracellular,Spaces, Intercellular
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000831	Animals, Newborn	Refers to animals in the period of time just after birth.	Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus