Biomaterial Database

Comparison of experimental and spontaneous bladder urothelial hyperplasias occurring in BALB/c mice. 1981

Y Shinohara, and C H Frith

Spontaneously occurring hyperplasia of urothelium of mice was compared morphologically to hyperplasia induced with 2-acetylaminofluorene (2-AAF) and 4-ethylsulfonylnaphthalene-1-sulfonamide (ENS). Simple and nodular hyperplasias were seen in all groups. Nodular downward hyperplasia was more commonly located in the vertex of the bladder of the 2-AAF treated mice but was more commonly located in the neck region of the ENS and control mice. The 2-AAF induced hyperplasia appeared to be capable of regression or progression to neoplasia. The ENS induced and the spontaneously occurring downward hyperplasia appeared to be secondary to a chronic cystitis and did not appear to progress to neoplasia.

UI	MeSH Term	Description	Entries
D006965	Hyperplasia	An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	Hyperplasias
D001743	Urinary Bladder	A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.	Bladder,Bladder Detrusor Muscle,Detrusor Urinae,Bladder Detrusor Muscles,Bladder, Urinary,Detrusor Muscle, Bladder,Detrusor Muscles, Bladder
D003556	Cystitis	Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.	Cystitides
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus