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The authors have observed 5 cases of cholestatic jaundice with cytolysis during treatment with amineptine, a new tricyclic compound recently made available. The responsibility of the drug was virtually certain for the following reasons: (a) there was no other cause of jaundice, such as viral infection, gallstones, toxic agents or association with other hepatotoxic drugs; (b) clinical and biochemical findings were similar in all patients; (c) in 2 patients, reintroduction of the drug after temporary withdrawal resulted in rapid recurrence of the condition, with the same symptoms and course. The shorter delay (2 and 8 days instead of 11 and 18 days) between absorption of amineptine and reappearance of the symptoms in these two patients is suggestive of an immunoallergic mechanism.
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
January 1981,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
January 1979,
L'Encephale,
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
February 1978,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
January 1981,
L'Encephale,
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
February 1974,
Clinica chimica acta; international journal of clinical chemistry,
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
April 1981,
Gastroenterologie clinique et biologique,
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
October 1981,
Zeitschrift fur Gastroenterologie,
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
January 1979,
L'Encephale,
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
October 1978,
La Nouvelle presse medicale,
P Bories, and
G Pomier-Layrargues, and
J P Chotard, and
D Citron, and
D Capron-Chivrac, and
J P Capron, and
H Michel
January 1980,
Acta gastro-enterologica Belgica,
