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In a series of in vitro experiments, the influence of bile salts on platelet aggregation by ADP or by collagen and on serotonin-14C release by collagen, was studied. Sodium salts of the following bile acids showed a clear inhibitory effect: glycochenodeoxycholic acid, taurochenodeoxycholic acid, glycocholic acid, taurocholic acid and cholic acid. Lowering the pH of the platelet-rich plasma resulted in decrease platelet aggregation by ADP and by collagen. Bile salts further enhanced the inhibitory effect of pH change. In contrast the sodium salt of chenodeoxycholic acid was the sole aggregation inducing bile salt we studied. Relating the above studies to the clinical situation of upper gastroduodenal mucosal haemorrhage, we suggest that biliary reflux as well as the acidic environment may contribute to a poor haemostatic response by impaired platelet aggregation in the upper gastrointestinal tract of otherwise normal human subjects.
G Baele, and
R Beke, and
F Barbier
November 1995,
Thrombosis research,
G Baele, and
R Beke, and
F Barbier
January 1979,
Acta medica Iugoslavica,
G Baele, and
R Beke, and
F Barbier
January 1991,
Journal of biochemical toxicology,
G Baele, and
R Beke, and
F Barbier
January 1980,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
G Baele, and
R Beke, and
F Barbier
December 1971,
Thrombosis et diathesis haemorrhagica,
G Baele, and
R Beke, and
F Barbier
January 2001,
Clinical hemorheology and microcirculation,
G Baele, and
R Beke, and
F Barbier
January 2002,
Acta medica Austriaca,
G Baele, and
R Beke, and
F Barbier
January 1964,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
G Baele, and
R Beke, and
F Barbier
December 1999,
International journal of pharmaceutics,
