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Two different AT-III fractions were purified from the plasma of a patient with recurrent superficial thrombophlebitis. The abnormal AT-III fraction (A-AT) was compared to the normal AT-III fraction (N-AT) in the inhibition of thrombin and factor Xa. Without heparin, both inactivate proteases in a similar manner and at the same rate. However, at low heparin concentration the thrombin inhibition proceeds more slowly with A-AT than with N-AT. At high heparin concentration the difference between A-AT and N-AT becomes very small. The inhibition of factor Xa follows a similar pattern. It is suggested that the heparin binding site of A-AT differs from that of N-AT resulting in a decreased heparin cofactor activity.
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
August 1984,
The Journal of laboratory and clinical medicine,
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
October 1984,
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire,
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
September 1984,
The Biochemical journal,
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
July 1983,
Thrombosis research,
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
December 1977,
Thrombosis research,
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
March 1993,
Thrombosis and haemostasis,
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
January 1983,
Haemostasis,
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
October 1988,
The Journal of biological chemistry,
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
July 1983,
Thrombosis research,
T H Tran, and
C Bondeli, and
G A Marbet, and
F Duckert
January 1980,
Thrombosis research,
