-transparent.png){kind=logo}
We have repeated as closely as possible the experiments of Zelac et al., who observed significantly elevated levels of chromosome aberrations in short-term cultures of peripheral lymphocytes from Chinese hamsters that had inhaled ozone. Unlike Zelac et al., we observed no increase in chromosome-type aberration levels, though a small increase in chromatid-aberration levels similar to that reported for exposed human subjects by Merz et al. was seen. No increase in the levels of any chromosomal aberration type was seen in parallel direct bone-marrow preparations. Sister-chromatid exchange (SCE) levels and cell-replication rates, which were determined in the Chinese hamster peripheral lymphocyte cultures and also in bone-marrow samples from similarly treated mice, failed to show any ozone-induced changes.
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
January 1977,
Mutation research,
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
December 1994,
Environmental health perspectives,
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
December 2016,
Biochimica et biophysica acta,
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
October 1976,
Environmental research,
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
July 2007,
Toxicology and applied pharmacology,
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
May 1980,
Radiation research,
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
February 1987,
Archives of toxicology,
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
May 1979,
The American review of respiratory disease,
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
September 1998,
Toxicology and applied pharmacology,
R R Tice, and
M A Bender, and
J L Ivett, and
R T Drew
June 2002,
Inhalation toxicology,
