The increased availability of platelets for transfusion has been a major factor in the improved prognosis noted in patients with acute nonlymphocytic leukemia. This review summarizes our current understanding of the proper use of platelet transfusion for patients with leukemia and cancer, with a particular emphasis on the management of alloimmunized patients. The need for careful and close collaboration between the blood bank and the referring clinicians is emphasized. Cryopreservation of autologous platelets, which can be of considerable assistance in the management of alloimmunized patients, and a summary of the large number of questions that still require further investigation are presented.