Biomaterial Database

Occupational exposure to halothane results in enzyme induction in anesthetists. 1981

P Duvaldestin, and R I Mazze, and Y Nivoche, and J M Desmonts

To determine whether exposure to trace concentrations of halothane resulted in enzyme induction, antipyrine pharmacokinetics were measured in six anesthetists before and after ten days of exposure to waste halothane. Antipyrine clearance increased by 29 per cent, a clinically small but statistically significant (P < 0.025) change, whereas the apparent volume of antipyrine distribution remained unchanged, indicating that halothane induces antipyrine metabolism. The implications of this finding for anesthetists cannot be simply defined. Enzyme induction may be beneficial or harmful, depending on the relative toxicities of the unbiotransformed parent compounds and their metabolites.

UI	MeSH Term	Description	Entries
D009873	Operating Rooms	Facilities equipped for performing surgery.	Operating Room,Room, Operating,Rooms, Operating
D004781	Environmental Exposure	The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.	Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D004790	Enzyme Induction	An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.	Induction, Enzyme
D006221	Halothane	A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)	1,1,1-Trifluoro-2-Chloro-2-Bromoethane,Fluothane,Ftorotan,Narcotan
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000395	Air Pollutants, Occupational	Toxic air-borne matter related to work performed They are usually produced by the specific nature of the occupation.	Occupational Air Pollutants,Pollutants, Occupational Air
D000776	Anesthesiology	A specialty concerned with the study of anesthetics and anesthesia.
D000983	Antipyrine	An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)	Phenazone,Anodynin,Pyramidone
D012463	Saliva	The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.	Salivas