Input conductance axonal conduction velocity and cell size among hindlimb motoneurones of the cat. 1981

D Kernell, and B Zwaagstra

Input conductance and axonal conduction velocity were measured for hindlimb motoneurones that were anatomically labelled by substances injected through the intracellular microelectrode (Procion dyes, horseradish peroxidase). We confirmed that there is a good correlation between the axonal conduction velocity of a hindlimb motoneurone and the size of its cell body. Furthermore, we confirmed that the power relation between neuronal input conductance and axonal conduction velocity has an exponent of about 3-4. If large motoneurones were simply scaled-up versions of the smaller ones, this exponent should have been between 1.5 and 2.0. We showed that the unexpectedly high input conductance of fast-axoned motoneurones, compared to that of the more slow-axoned ones, was not due to a corresponding disproportion between the axonal conduction velocity and the size of the cell body. Neither could it be explained by differences between large and small cells with respect to the relative sizes and numbers of dendritic stems. The unexpectedly high input conductance of large cells seems likely to be largely caused by a lower average value for the specific membrane resistance among these cells than among the smaller ones. Hitherto unknown differences in dendritic architecture between large and smaller cells might conceivably be of some importance as well. Our results are consistent with the view that, in muscle contractions evoked by the central nervous system, thin-axoned motoneurones might be recruited more easily than more thick-axoned ones even if all the cells were activated by the same density of equipotent synapses.

UI MeSH Term Description Entries
D009046 Motor Neurons Neurons which activate MUSCLE CELLS. Neurons, Motor,Alpha Motorneurons,Motoneurons,Motor Neurons, Alpha,Neurons, Alpha Motor,Alpha Motor Neuron,Alpha Motor Neurons,Alpha Motorneuron,Motoneuron,Motor Neuron,Motor Neuron, Alpha,Motorneuron, Alpha,Motorneurons, Alpha,Neuron, Alpha Motor,Neuron, Motor
D009431 Neural Conduction The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus. Nerve Conduction,Conduction, Nerve,Conduction, Neural,Conductions, Nerve,Conductions, Neural,Nerve Conductions,Neural Conductions
D011999 Recruitment, Neurophysiological The spread of response if stimulation is prolonged. (Campbell's Psychiatric Dictionary, 8th ed.) Recruitment, Motor Unit,Motor Unit Recruitment,Neurophysiological Recruitment
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D003712 Dendrites Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS. Dendrite
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D006614 Hindlimb Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73) Hindlimbs
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001369 Axons Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body. Axon

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