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[Drug treatment of benign breast diseases]. 1980

K D Schulz

During the last decade many new experimental and clinical data were published demonstrating the inclusion of estrogens, progestagens, androgens, corticosteroids, prolactin, growth hormone and of insulin in the endocrine control of normal mammary tissue. Different hormonal disorders, such as lowered progesterone-estrogen-index (P.E.I.), anovulation, hyperprolactinemia, or increased prolactin-sensitivity of mammary tissue, are often responsible for the induction and/or maintenance of benign breast disease. therefore the endocrine treatment possesses deciding importance for the improvement or removal of breast symptoms. The present paper evaluates the role of progestagens, prolactin-inhibitors or anti-gonadotropins in the differentiated therapy of mastodynia, mastopathia, mammary secretion, mastitis, mammary hyperplasia, premenstrual syndrome and other disturbances. Dose levels and side effects of the various drugs are reviewed. The relation to other therapeutic procedures, as non-hormonal preparations or operative methods, is discussed.

UI MeSH Term Description Entries
D008413 Mastitis INFLAMMATION of the BREAST, or MAMMARY GLAND.
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011248 Pregnancy Complications Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases. Adverse Birth Outcomes,Complications, Pregnancy,Adverse Birth Outcome,Birth Outcome, Adverse,Complication, Pregnancy,Outcome, Adverse Birth,Pregnancy Complication
D011388 Prolactin A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate. Lactogenic Hormone, Pituitary,Mammotropic Hormone, Pituitary,Mammotropin,PRL (Prolactin),Hormone, Pituitary Lactogenic,Hormone, Pituitary Mammotropic,Pituitary Lactogenic Hormone,Pituitary Mammotropic Hormone
D001941 Breast Diseases Pathological processes of the BREAST. Endocrine Breast Diseases,Breast Disease,Breast Disease, Endocrine,Breast Diseases, Endocrine,Disease, Breast,Disease, Endocrine Breast,Diseases, Breast,Diseases, Endocrine Breast,Endocrine Breast Disease
D001971 Bromocriptine A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion. 2-Bromoergocryptine,Bromocryptin,2-Bromo-alpha-ergocryptine,2-Bromo-alpha-ergokryptine,2-Bromoergocryptine Mesylate,2-Bromoergocryptine Methanesulfonate,2-Bromoergokryptine,Bromocriptin,Bromocriptine Mesylate,CB-154,Parlodel,2 Bromo alpha ergocryptine,2 Bromo alpha ergokryptine,2 Bromoergocryptine,2 Bromoergocryptine Mesylate,2 Bromoergocryptine Methanesulfonate,2 Bromoergokryptine,CB 154,CB154,Mesylate, 2-Bromoergocryptine,Mesylate, Bromocriptine,Methanesulfonate, 2-Bromoergocryptine
D003613 Danazol A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. Azol,Cyclomen,Danatrol,Danazant,Danazol-Ratiopharm,Danocrine,Danol,Danoval,Ladogal,Norciden,Panacrine,Danazol Ratiopharm
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D045167 Progesterone Congeners Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities. Synthetic Progestin,Progestagens, Synthetic,Progestational Hormone Analogs,Progestational Hormone Analogues,Progestational Hormones, Synthetic,Progestin Analogs,Progestin Analogues,Progestins, Synthetic,Progestogens, Synthetic,Synthetic Progestational Hormones,Synthetic Progestins,Progestin, Synthetic,Synthetic Progestagens,Synthetic Progestogens

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