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A newly developed high-pressure liquid chromatographic method was used to study the optimum dosage regimen needed to suppress endogenous hydrocortisone. Nine volunteers were randomly placed in three groups. Each group received 1 mg of dexamethasone at 11 pm (Treatment A), 2 mg of dexamethasone at 11 pm (Treatment B), or 1 mg at 11 pm and an additional 1 mg at 6 am the following day (Treatment C). Analysis of multiple blood samples obtained the day before and the day after drug administration showed suppression in all three groups. Although the duration and extent of this suppression varied, adequate suppression to permit bioavailability studies was observed for Treatments B and C.
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
June 2015,
Journal of veterinary pharmacology and therapeutics,
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
April 1982,
Journal of pharmacokinetics and biopharmaceutics,
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
August 1985,
Psychiatry research,
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
July 1982,
Orvosi hetilap,
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
January 1984,
European archives of psychiatry and neurological sciences,
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
February 2005,
Journal of veterinary pharmacology and therapeutics,
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
June 1987,
Psychiatry research,
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
September 1985,
Journal of affective disorders,
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
April 1983,
Acta psychiatrica Scandinavica,
T J Goehl, and
G M Sundaresan, and
J P Hunt, and
V K Prasad, and
R D Toothaker, and
P G Welling
January 1988,
Psychiatria polska,
