Biomaterial Database

The effects of pimozide during pairing on the transfer of classical conditioning to an operant discrimination. 1981

R J Beninger, and A G Phillips

Transfer of classical conditioning to operant learning was demonstrated by showing enhanced acquisition of an operant discrimination in a group of rats (n = 6) previously exposed to pairings of the discriminative stimulus with food as compared to control animals (n = 6). A group (n = 6) that received the classical conditioning sessions while under the influence of the neuroleptic, pimozide (1.0 mg/kg, IP) also showed enhanced acquisition of the discrimination when tested while undrugged but their performance was intermediate between that of the other groups for the first seven sessions. For the remaining sessions, the two groups that had received classical conditioning did not differ from each other and both groups discriminated better than the controls. These data may indicate a role for dopaminergic neurons in the mechanism by which the effects of classical conditioning influence operant responding.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010868	Pimozide	A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)	Antalon,Orap,Orap forte,R-6238,R6238
D012055	Reinforcement Schedule	A schedule prescribing when the subject is to be reinforced or rewarded in terms of temporal interval in psychological experiments. The schedule may be continuous or intermittent.	Reinforcement Schedules,Schedule, Reinforcement,Schedules, Reinforcement
D003214	Conditioning, Classical	Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.	Reflex, Conditioned,Classical Conditioning,Classical Conditionings,Conditioned Reflex,Conditionings, Classical
D003216	Conditioning, Operant	Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced.	Instrumental Learning,Learning, Instrumental,Operant Conditioning,Conditionings, Operant,Instrumental Learnings,Learnings, Instrumental,Operant Conditionings
D004193	Discrimination Learning	Learning that is manifested in the ability to respond differentially to various stimuli.	Discriminative Learning,Discrimination Learnings,Discriminative Learnings,Learning, Discrimination,Learning, Discriminative
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus