Biomaterial Database

[Physiology and pathophysiology of bile secretion]. 1980

S Konturek

After introductory anatomical considerations a survey is given of the composition of bile and the physiology of bile secretion. According to the modern conception the bile acids give the osmotic power for the excretion of water and electrolytes. Apart from this, a bile fraction, which is also secreted by the liver cells into the canaliculi, is present, and in the biliary ducts a further volume fraction independent of bile acid is added, the secretion of which is determined by gastrointestinal hormones. Processes of reabsorption play a role particularly in the gallbladder. By formation of micelles the bile salts render the excretion of cholesterol possible. A normal bile secretion is necessary for the normal emulgation, digestion and absorption of the fats.

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D008055	Lipids	A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)	Lipid
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008102	Liver Circulation	The circulation of BLOOD through the LIVER.	Hepatic Circulation,Circulation, Liver,Circulation, Hepatic
D002763	Cholecystectomy	Surgical removal of the GALLBLADDER.	Cholecystectomies
D002769	Cholelithiasis	Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).	Gallstone Disease,Cholelithiases,Gallstone Diseases
D004573	Electrolytes	Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	Electrolyte
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001646	Bile	An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.	Biliary Sludge,Sludge, Biliary
D001647	Bile Acids and Salts	Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.	Bile Acid,Bile Salt,Bile Salts,Bile Acids,Acid, Bile,Acids, Bile,Salt, Bile,Salts, Bile