Biomaterial Database

[Local application of prostaglandins by means of a portio-adapter: A new method of induction of labor (author's transl)]. 1980

P Husslein, and W Grünberger, and J Huber

In 102 pregnant women with low cervix-scores (37th-42nd week of gestation) 1,25 mg PGE2 were applied to the cervix uteri by means of a portio-adapter. In 69 cases (67,6%) labor was induced. In 7 cases additional 0,75 mg PGE2 were instilled after 6h. in 9 women the portio-adapter was applied a second time the next day (in 4 of these even a third time). In 17 cases amniotomy was performed the next day. 11 patients (10,8%) were delivered by Cesarian section or low forceps, one women was discharged from hospital, all other delivered spontaneously. In 15 consecutive spontanous deliveries the pH of the V. umbilicalis was 7,29 +/- 0,12, the arterial pH 7,23 +/- 0,15. Intrauterine tocography revealed a uterine hyperactivity with no dystocie. When prostaglandins are applied to the cervix by means of a portio-adapter, the preparation of a gel-mixture can be avoided, an exact anatomic localisation of the therapeutic solutions is provided and the prostaglandins can be withdrawn at least partly in case of hyperstimulation. Another advantage of this from this induction is that the women are not confined to their bed until shortly before delivery.

UI	MeSH Term	Description	Entries
D007751	Labor, Induced	Artificially induced UTERINE CONTRACTION.	Induced Labor,Induction of Labor,Labor Induced,Labor Induction,Induced, Labor,Induction, Labor,Inductions, Labor,Labor Inductions
D009774	Obstetrics	A medical-surgical specialty concerned with management and care of women during pregnancy, parturition, and the puerperium.
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011458	Prostaglandins E	(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.	PGE
D002584	Cervix Uteri	The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.	Cervical Canal of the Uterus,Cervical Canal, Uterine,Ectocervix,Endocervical Canal,Endocervix,External Os Cervix,External Os of the Cervix,Uterine Cervical Canal,Cervix,Cervixes,Uterine Cervix,Canal, Endocervical,Canal, Uterine Cervical,Cervix, External Os,Cervix, Uterine,Endocervical Canals,Uterine Cervical Canals
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000287	Administration, Topical	The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.	Drug Administration, Topical,Administration, Topical Drug,Topical Administration,Topical Drug Administration,Administrations, Topical,Administrations, Topical Drug,Drug Administrations, Topical,Topical Administrations,Topical Drug Administrations