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This study points to the controversy over the anti-depressant efficacy of tricyclic antidepressant drugs (TAD) and emphasize their cardiotoxicity. The number of lethal poisoning cases--from the Swiss federal statistics on the cause of death--amounted to 54 for the period from 1967 to 1976. Ten of these 54 cases occurred in children who had ingested the drug accidentally; the remaining cases concerned adults who took an overdose of the drug intentionally. In addition, the authors reviewed the forensic medical examinations performed on 11 cases of unexpected death due to lethal poisoning with TAD. Our data indicated that fatality can follow drug intake quite rapidly. Autoptical and histological findings were not specific. To confirm a poisoning diagnosis, levels of TAD and their metabolites were therefore determined in nine cases in various organ tissues and body fluids. Poisoning was due to imipramine (3 cases), opipramol (2 cases), dibenzepine (3 cases), and amitriptyline (3 cases).
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
January 1979,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
January 1981,
MMW, Munchener medizinische Wochenschrift,
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
May 1975,
Deutsche medizinische Wochenschrift (1946),
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
April 1980,
Medicina clinica,
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
July 1998,
Journal of the American Academy of Child and Adolescent Psychiatry,
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
February 1974,
Praxis der Pneumologie,
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
March 1978,
Die Medizinische Welt,
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
January 1980,
Annales de medecine interne,
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
August 1974,
Ceskoslovenska gynekologie,
H Häner, and
H Brandenberger, and
A Pasi, and
T Moccetti, and
H Hartmann
June 1978,
Medizinische Klinik,
