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Styrene is rapidly metabolized in humans to mandelic () and phenylglyoxylic acids (P) which are excreted in urine. The present study investigates a gas chromatographic technique for measuring urinary concentrations of MA and PGA of workers exposed to styrene, compares the urinary concentrations of metabolites with time-weighted average air exposures to styrene and determines the levels of these metabolites in a population of workers not exposed to styrene. Post-shift urine specimens were obtained from a group of workers exposed to styrene in the reinforced plastic industry and from a control group. High positive correlation was found between post-shift urinary concentrations of metabolites and 8-hour TWA styrene exposure. Both MA and total metabolites (MA + PGA) gave correlation coefficient values of 0.96, p less than 0.0001. The mean MA excretion for the control groups was 6 mg/L. Determination of the concentration of these metabolites in a post-shift urine provides an effective means of estimating and monitoring human exposure to styrene.
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
January 1990,
Journal of analytical toxicology,
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
January 1983,
Developments in toxicology and environmental science,
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
January 1984,
Journal of hygiene, epidemiology, microbiology, and immunology,
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
April 1970,
British journal of industrial medicine,
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
January 1993,
International archives of occupational and environmental health,
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
April 2001,
Journal of chromatography. B, Biomedical sciences and applications,
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
November 1978,
American Industrial Hygiene Association journal,
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
August 1979,
British journal of industrial medicine,
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
May 1990,
Canadian journal of physiology and pharmacology,
V J Elia, and
L A Anderson, and
T J Macdonald, and
A Carson, and
C R Buncher, and
S M Brooks
January 1978,
Scandinavian journal of work, environment & health,
