Biomaterial Database

Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors. 1980

M Pollard, and P H Luckert

Intestinal tumors were induced in male Sprague-Dawley rats following the administration of five weekly doses of 1,2-dimethylhydrazine (DMH) by gavage. At intervals thereafter, groups of rats were given indomethacin (IND) in the drinking water. In three trials, the incidence of rats with tumors was significantly reduced by 40% below the control rats which did not receive IND and there was no significant difference in body weights. Also, in those IND-treated rats which developed tumors, the tumors were generally smaller in numbers and sizes compared to the control rats. A group of DMH-treated rats was treated with crude IND by gavage and the differences between them and untreated control rats were not significant. It is likely that the treatment was directed at the tumors and not at the DMH which induced them.

UI	MeSH Term	Description	Entries
D007213	Indomethacin	A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.	Amuno,Indocid,Indocin,Indomet 140,Indometacin,Indomethacin Hydrochloride,Metindol,Osmosin
D007414	Intestinal Neoplasms	Tumors or cancer of the INTESTINES.	Cancer of Intestines,Intestinal Cancer,Cancer of the Intestines,Intestines Cancer,Intestines Neoplasms,Neoplasms, Intestinal,Cancer, Intestinal,Cancer, Intestines,Cancers, Intestinal,Cancers, Intestines,Intestinal Cancers,Intestinal Neoplasm,Intestines Cancers,Intestines Neoplasm,Neoplasm, Intestinal,Neoplasm, Intestines,Neoplasms, Intestines
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D008763	Methylhydrazines	Hydrazines substituted by one or more methyl groups in any position.
D009374	Neoplasms, Experimental	Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.	Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D004127	Dimethylhydrazines	Hydrazines substituted with two methyl groups in any position.	Dimethylhydrazine