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The effects of large and oral doses of ascorbic acid on renal clearance and excretion of uric acid were studied in nongouty subjects because ascorbic acid has been reported to increase renal uric acid clearance. Our results indicate that 4 or 12 gm ascorbic acid taken in divided doses had no effect on serum uric acid concentration or uric acid excretion and clearance by the kidney. Reasons for these results, which differ from previous reports, are discussed. We quantitated the magnitude of the interference of ascorbic acid in the measurement of uric acid by the nonspecific methods frequently used, since falsely elevated urine uric acid could lead to misinterpretation of screening tests.
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
January 1962,
Ceskoslovenska gynekologie,
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
January 1977,
The American journal of medicine,
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
February 1981,
Acta pharmacologica et toxicologica,
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
December 1965,
Archives of interamerican rheumatology : A.I.R,
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
January 1975,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
June 1978,
The Journal of pediatrics,
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
January 1963,
Voprosy pitaniia,
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
August 1959,
The New England journal of medicine,
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
January 1980,
Casopis lekaru ceskych,
W E Mitch, and
M W Johnson, and
J M Kirshenbaum, and
R E Lopez
February 1955,
The Journal of clinical investigation,
