-transparent.png){kind=logo}
The effect of dose on acetylator phenotype distribution of hydralazine has been determined, The acetylated metabolites methyltriazolophthalazine (MTP) and 3-hydroxymethyltriazolophthalazine (3-OHMTP) and acid-labile hydralazine (HP) were determined in the 0- to 24-hr urine of patients receiving various doses. The difference between the mean value for the ration 3-OHMTP:HP in the rapid and slow acetylators varied with dose, the greatest difference being after a 200 mg (100 mg twice daily) dose. The distribution of the ratio became less clearly bimodal at lower doses, with overlap between phenotypes occurring at doses of 100 mg (50 mg twice daily) or less. The most effective dose for discriminating between acetylator phenotypes was found to be 200 mg (100 mg twice daily).
J A Timbrell, and
S J Harland, and
V Facchini
January 1984,
The Netherlands journal of medicine,
J A Timbrell, and
S J Harland, and
V Facchini
April 1975,
Acta medica Scandinavica,
J A Timbrell, and
S J Harland, and
V Facchini
January 1976,
Acta medica Scandinavica,
J A Timbrell, and
S J Harland, and
V Facchini
January 1981,
Hypertension (Dallas, Tex. : 1979),
J A Timbrell, and
S J Harland, and
V Facchini
January 1984,
European journal of clinical pharmacology,
J A Timbrell, and
S J Harland, and
V Facchini
December 1986,
Clinical pharmacology and therapeutics,
J A Timbrell, and
S J Harland, and
V Facchini
April 1981,
British journal of clinical pharmacology,
J A Timbrell, and
S J Harland, and
V Facchini
February 1980,
Journal of pharmacokinetics and biopharmaceutics,
J A Timbrell, and
S J Harland, and
V Facchini
June 1981,
Ugeskrift for laeger,
J A Timbrell, and
S J Harland, and
V Facchini
October 1974,
Annals of clinical research,
