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A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors. 1995
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
URA 1387 CNRS, Synthèse Organique, Institut Curie, Section de Recherche, Orsay, France.
4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)-pyridinone hybrid molecules. Biological studies revealed that some of them show potent HIV-1 specific reverse transcriptase inhibitory properties. Compounds 16 and 7c, the most active ones, inhibit the replication of HIV-1 at 3 and 6 nM, respectively.
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V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
October 2000,
Journal of medicinal chemistry,
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
August 1991,
Proceedings of the National Academy of Sciences of the United States of America,
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
June 2009,
Journal of medicinal chemistry,
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
September 1991,
Journal of virology,
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
January 2010,
Current medicinal chemistry,
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
January 2004,
Current topics in medicinal chemistry,
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
January 2018,
Antiviral chemistry & chemotherapy,
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
March 1999,
Antiviral chemistry & chemotherapy,
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
May 1995,
Journal of medicinal chemistry,
V Dollé, and
E Fan, and
C H Nguyen, and
A M Aubertin, and
A Kirn, and
M L Andreola, and
G Jamieson, and
L Tarrago-Litvak, and
E Bisagni
February 1994,
The Journal of antimicrobial chemotherapy,
