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We devised a method for evaluating polymorphonuclear leukocyte (PMN) infiltration in vivo employing an air bleb technique combined with measurement of myeloperoxidase (MPO) activity, and the effects of some anti-platelet agents were evaluated. KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]pyrrol-1-ylacetate) and cilostazol inhibited the increase in MPO activity in the connective tissue around the air bleb induced by leukotriene B4 (LTB4) and formyl-methionyl-leucyl-phenylalanine (fMLP). Indomethacin inhibited only the fMLP-induced increase in MPO activity, but ticlopidine hydrochloride and acetylsalicylic acid had no effect. Histologic observation confirmed the inhibition of PMN infiltration by KBT-3022. These results indicate that KBT-3022 may be a potent inhibitor of both LTB4- and fMLP-induced infiltration of PMNs.
K Yokota, and
N Yamamoto, and
Y Obata, and
M Oda
September 1986,
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K Yokota, and
N Yamamoto, and
Y Obata, and
M Oda
June 1985,
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K Yokota, and
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June 2004,
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K Yokota, and
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February 1989,
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K Yokota, and
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M Oda
February 1984,
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K Yokota, and
N Yamamoto, and
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M Oda
October 1984,
Biochemical pharmacology,
K Yokota, and
N Yamamoto, and
Y Obata, and
M Oda
January 1986,
Voprosy meditsinskoi khimii,
K Yokota, and
N Yamamoto, and
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M Oda
April 1982,
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K Yokota, and
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M Oda
February 1997,
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K Yokota, and
N Yamamoto, and
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M Oda
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