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The pathogenesis of Wegener's granulomatosis, microscopic polyangiitis and idiopathic rapidly progressive glomerulonephritis (RPGN) is still unclear; in vitro data support both humoral and cellular autoimmune mechanisms. An association of Wegener's granulomatosis with HLA antigens has been described, with conflicting results concerning the antigens involved. We have performed serological HLA typing of patients at two different laboratories within the Netherlands (N = 118 and N = 106,N respectively). A significant decrease in the frequency of HLA-DR13DR6 was present in both patient groups in comparison to controls (chi 2 = 21.9; corrected P value < 0.004 for both groups together). There were no differences in the distribution of HLA-antigens between patients with Wegener's granulomatosis and microscopic polyangiitis, between cANCA (cytoplasmic anti-neutrophil cytoplasmic antibodies) and pANCA (perinuclear ANCA, anti-MPO) positive patients, and between patients with and without relapsing disease.
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
October 1991,
Clinical otolaryngology and allied sciences,
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
October 1979,
Clinical immunology and immunopathology,
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
February 1978,
Tissue antigens,
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
August 2008,
Arthritis and rheumatism,
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
January 1983,
Arthritis and rheumatism,
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
April 2014,
Rheumatology international,
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
January 1981,
Archives of oto-rhino-laryngology,
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
September 1961,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
December 1969,
Archivos de oftalmologia de Buenos Aires,
E C Hagen, and
C A Stegeman, and
J D'Amaro, and
G M Schreuder, and
S P Lems, and
J W Tervaert, and
G M de Jong, and
R J Hené, and
C G Kallenberg, and
M R Daha
December 1981,
Klinicheskaia meditsina,
