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Monte Carlo methods are used to analyze the stochastic interaction between ATP, released in a packet at a bouton, and the underlying patch of purinoceptors. The time-course of the average quantal current recorded with an intracellular electrode in the peripheral and central nervous systems is reconstructed, given the geometry of the synapse and the known kinetics of ATP action. This leads to certain restrictions on the possible numbers of ATP molecules in a quantum and the density of purinoceptors at the synapses. The addition of an ectoenzyme into the synaptic cleft with the known kinetics of ATPase gives rise to a quantal current of appropriate time-course if the number of ATP molecules in a quantum is increased over that in the absence of the ATPase. The stochastic variability in the quantal current is less than 0.1 for a given size quantum.
M R Bennett, and
L Farnell, and
W G Gibson
October 2004,
Journal of neurophysiology,
M R Bennett, and
L Farnell, and
W G Gibson
January 2016,
Neuromethods,
M R Bennett, and
L Farnell, and
W G Gibson
May 1994,
Brain research,
M R Bennett, and
L Farnell, and
W G Gibson
January 1994,
Advances in second messenger and phosphoprotein research,
M R Bennett, and
L Farnell, and
W G Gibson
January 1989,
Neuroscience,
M R Bennett, and
L Farnell, and
W G Gibson
August 2007,
Nature reviews. Neuroscience,
M R Bennett, and
L Farnell, and
W G Gibson
April 1997,
The European journal of neuroscience,
M R Bennett, and
L Farnell, and
W G Gibson
July 2000,
Journal of the autonomic nervous system,
M R Bennett, and
L Farnell, and
W G Gibson
January 1992,
Functional neurology,
M R Bennett, and
L Farnell, and
W G Gibson
August 1995,
Proceedings. Biological sciences,
