Measurement of gamma-glutamyl transpeptidase and gamma-glutamylcysteine synthetase activities in cells.
1995
H J Forman, and
M M Shi, and
T Iwamoto, and
R M Liu, and
T W Robison
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles 90033, USA.
UI
MeSH Term
Description
Entries
D005721
Glutamate-Cysteine Ligase
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.