-transparent.png){kind=logo}
Mouse peritoneal macrophages release a factor(s) that stimulates differentiation of a mouse myeloid leukaemic cell line into mature granulocytes and macrophages. Treatment of the macrophages with the synthetic double-stranded polyribonucleotides poly(I).poly(C) and poly(A).poly(U) resulted in enhanced release of the factor into the culture medium. The effect was maximal after treatment with polyribonucleotides for 1 h, and the optimal dose of poly(I).poly(C) was 50 microgram/ml. The single-stranded polyribonucleotides poly(I) and poly(C) at the same concentration were far less effective. The differentiation-stimulating factor was detected not only in the cultured medium but also in the cell lysate. Exposure of macrophages to poly(I).poly(C) enhanced the total activity of the factor in both the culture medium and the cell lysate. The effect of this compound was blocked by the presence of cycloheximide. These results suggest that double-stranded polyribonucleotides enhance production of the differentiation-stimulating factor by peritoneal macrophages.
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
December 1981,
Gan,
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
February 1978,
Experimental cell research,
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
October 1979,
Cancer research,
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
December 1980,
Cancer research,
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
August 1977,
Gan,
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
June 1981,
Cancer research,
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
November 1996,
Immunopharmacology,
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
May 1981,
Cancer research,
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
May 1989,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
M Tomida, and
K Takenaga, and
Y Yamamoto, and
M Hozumi
March 1980,
Journal of the Reticuloendothelial Society,
