-transparent.png){kind=logo}
A new met-enkephalin analogue (compound 82/205) was evaluated for its opioidergic activity in mice. The compound showed antinociception (warm water tail-flick test), tolerance, cross tolerance to morphine and physical dependence. The time course of antinociceptive effect of the compound was comparable to morphine. The antinociceptive ED50 (mumol kg-1, i.p.) values for the compound and morphine base were 5.31 and 7.59, respectively. Its antinociceptive effect was blocked by naloxone, beta-FNA (mu antagonist) and naloxonazine (mu1 antagonist) but not by ICI 174,864 (delta antagonist). Naloxone precipitated withdrawal jumpings were 2.6 times less in compound 82/205 treated mice than the morphine treated group. The new analogue compound 82/205 is a potent mu agonist antinociceptive with a possible weak dependence liability.
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
September 2004,
Bioorganic & medicinal chemistry letters,
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
April 1983,
NIDA research monograph,
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
December 1981,
Indian journal of biochemistry & biophysics,
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
January 1999,
Life sciences,
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
January 1982,
Peptides,
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
January 2019,
Bioorganic & medicinal chemistry letters,
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
December 1987,
Life sciences,
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
January 1997,
Immunopharmacology,
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
November 1990,
The Journal of endocrinology,
C Nath, and
G K Patnaik, and
W Haq, and
K B Mathur, and
R C Srimal, and
B N Dhawan, and
F Porreca
March 2002,
Life sciences,
