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A functional connection, evidenced by synergism and cross-tolerance, seems to exist between the mu-opioid and the alpha 2-adrenergic receptors in the superficial dorsal horn of the rat spinal cord. In this study possible cross-antagonism between these systems was studied by intrathecal administration of morphine 2.5 micrograms or dexmedetomidine 1.25 micrograms 15 min. after subcutaneous injection of naloxone 1.0 mg/kg or atipamezole 3.0 mg/kg in the morphine group and 4.0 mg/kg or 1.0 mg/kg in the dexmedetomidine group, respectively. No cross-antagonism of the antinociceptive effect was seen either in the tail flick or in the hot plate test at 15, 30, 45 and 60 min. from the pretreatment.
V K Kontinen, and
E A Kalso
May 1993,
The Journal of pharmacology and experimental therapeutics,
V K Kontinen, and
E A Kalso
December 2003,
Molecular pharmacology,
V K Kontinen, and
E A Kalso
August 1999,
Neuroreport,
V K Kontinen, and
E A Kalso
May 1992,
Neuroscience letters,
V K Kontinen, and
E A Kalso
July 1999,
Journal of anatomy,
V K Kontinen, and
E A Kalso
August 1992,
Archives des maladies du coeur et des vaisseaux,
V K Kontinen, and
E A Kalso
February 2008,
Nature chemical biology,
V K Kontinen, and
E A Kalso
February 1982,
Neuropharmacology,
V K Kontinen, and
E A Kalso
March 1999,
Brain research,
