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A group of 8 structurally modified norbornane analogs, selected on basis of water solubility, was tested for its potential cytotoxic effects using a modified MTT assay. Four tumor cell lines, three hematological and a hepatocellular one were used as an experimental model system. Some analogs exhibited an antitumor effect which was shown to be tissue specific. The cytotoxic effect is most likely due to the nature of the side chains rather than to the basic bicyclic norbornane structure of the molecule. These results not only provide a basis for the synthesis of derivatives with effective antitumor activity, but also give some indication of the the molecular target of these compounds.
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
August 1989,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
June 1988,
British journal of cancer,
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
October 1998,
Archiv der Pharmazie,
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
December 2014,
Naunyn-Schmiedeberg's archives of pharmacology,
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
November 1990,
Gynecologic oncology,
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
September 2013,
Bioorganic & medicinal chemistry letters,
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
January 1988,
Developments in biological standardization,
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
January 2002,
Anticancer research,
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
December 2005,
Toxicology in vitro : an international journal published in association with BIBRA,
W Jäger, and
B Päsler, and
G Buchbauer, and
P Chiba
May 2017,
Pakistan journal of pharmaceutical sciences,
