BIOMAT Database Logo BIOMAT Database Logo

Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats. 1995

N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.

The effects of the prostacyclin analog beraprost sodium on motor nerve function and nerve blood-flow were examined in streptozotocin-induced diabetic rats. Oral administration of beraprost sodium 0.1 mg/kg/day for 8 wks significantly (P < 0.001) improved caudal motor nerve conduction velocity and sciatic nerve blood-flow, both of which are impaired in diabetic rats. Beraprost sodium did not affect glucose, sorbitol, or fructose levels in the sciatic nerve. However, a decreased content of cyclic AMP in the sciatic nerve and higher level of thromboxane B2 in the thoracic aorta of diabetic rats, as compared with those in normal rats, were reversed by the treatment with beraprost sodium (P < 0.01). Results suggest that beraprost sodium may have value in treating diabetic neuropathy, mainly by improving endoneurial blood-flow.

UI MeSH Term Description Entries
D008297 Male Males
D009046 Motor Neurons Neurons which activate MUSCLE CELLS. Neurons, Motor,Alpha Motorneurons,Motoneurons,Motor Neurons, Alpha,Neurons, Alpha Motor,Alpha Motor Neuron,Alpha Motor Neurons,Alpha Motorneuron,Motoneuron,Motor Neuron,Motor Neuron, Alpha,Motorneuron, Alpha,Motorneurons, Alpha,Neuron, Alpha Motor,Neuron, Motor
D009131 Muscle, Smooth, Vascular The nonstriated involuntary muscle tissue of blood vessels. Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D009431 Neural Conduction The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus. Nerve Conduction,Conduction, Nerve,Conduction, Neural,Conductions, Nerve,Conductions, Neural,Nerve Conductions,Neural Conductions
D010975 Platelet Aggregation Inhibitors Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. Antiaggregants, Platelet,Antiplatelet Agent,Antiplatelet Agents,Antiplatelet Drug,Blood Platelet Aggregation Inhibitor,Blood Platelet Antagonist,Blood Platelet Antiaggregant,PAR-1 Antagonists,Platelet Aggregation Inhibitor,Platelet Antagonist,Platelet Antagonists,Platelet Antiaggregant,Platelet Antiaggregants,Platelet Inhibitor,Protease-Activated Receptor-1 Antagonists,Antiplatelet Drugs,Blood Platelet Aggregation Inhibitors,Blood Platelet Antagonists,Blood Platelet Antiaggregants,Platelet Inhibitors,Agent, Antiplatelet,Aggregation Inhibitor, Platelet,Antagonist, Blood Platelet,Antagonist, Platelet,Antiaggregant, Blood Platelet,Antiaggregant, Platelet,Drug, Antiplatelet,Inhibitor, Platelet,Inhibitor, Platelet Aggregation,PAR 1 Antagonists,Platelet Antagonist, Blood,Platelet Antiaggregant, Blood,Protease Activated Receptor 1 Antagonists
D011464 Epoprostenol A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY). Prostacyclin,Prostaglandin I2,Epoprostanol,Epoprostenol Sodium,Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer,Flolan,Prostaglandin I(2),Veletri
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D012039 Regional Blood Flow The flow of BLOOD through or around an organ or region of the body. Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete

Related Publications

N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
Prevention and reversal of motor and sensory peripheral nerve conduction abnormalities in streptozotocin-diabetic rats by the prostacyclin analogue iloprost.
May 1993, Naunyn-Schmiedeberg's archives of pharmacology,
N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
Effects of beraprost sodium, a prostacyclin analogue, on diabetic neuropathy in streptozotocin-induced diabetic rats.
February 1996, Japanese journal of pharmacology,
N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
Beneficial action of beraprost sodium, a prostacyclin analog, in stroke-prone rats.
September 1997, Journal of cardiovascular pharmacology,
N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
Effects of chronic treatment with a nitric oxide donor on nerve conduction abnormalities and endoneurial blood flow in streptozotocin-diabetic rats.
January 1995, European journal of clinical investigation,
N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
A prostacyclin analog beraprost sodium attenuates radiocontrast media-induced LLC-PK1 cells injury.
May 2004, Kidney international,
N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
Conduction velocity of motor nerve and cervical sympathetic and vagus nerve in streptozotocin diabetic rats.
May 1990, Neuroscience letters,
N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
Effects of the PGI2 analog beraprost sodium on glomerular prostanoid synthesis in rats with streptozotocin-induced diabetes.
January 1996, Nephron,
N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
Amelioration of diabetic nephropathy in OLETF rats by prostaglandin I(2) analog, beraprost sodium.
January 2009, American journal of nephrology,
N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve.
August 2001, Diabetes,
N Hotta, and N Koh, and F Sakakibara, and J Nakamura, and Y Hamada, and T Wakao, and T Hara, and K Mori, and K Naruse, and W Nakashima
The prostacyclin analog beraprost sodium ameliorates characteristics of metabolic syndrome in obese Zucker (fatty) rats.
April 2010, Diabetes,
Copied contents to your clipboard!