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Cooper and associates (1973) developed a method of ascertaining the lithium dosage required to attain a therapeutic serum level of 0.6 to 1.2 mEq/L. However, reports about the safety and accuracy of their method in children are limited (Geller & Fetner 1989). This study relates our experience with using this method in children. Subjects were 16 conduct-disordered children (13 males, 3 females), ages 8.97 to 17.14 years (mean, 12.73 +/- 2.12), who were treated with lithium to decrease aggressive behavior. Following a lithium 600-mg loading dose, a 24-hour serum lithium level was drawn from which a "predicted" lithium dosage was established. These dosages ranged from 600 to 1,800 mg/day (mean, 1,312.5 +/- 450) and the corresponding serum lithium levels at steady-state ranged from 0.58 to 1.13 mEq/L (mean, 0.87 +/- 0.15). No severe side effects were encountered. This suggests that the method is safe and useful for predicting lithium dosages in children.
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
April 1986,
The Journal of clinical psychiatry,
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
January 1988,
Acta paediatrica Hungarica,
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
May 1994,
The Journal of clinical psychiatry,
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
October 1992,
Journal of clinical psychopharmacology,
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
September 1988,
The Journal of clinical psychiatry,
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
June 1984,
The American journal of psychiatry,
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
January 1989,
Indian journal of psychiatry,
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
June 1988,
Biological psychiatry,
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
January 1991,
International clinical psychopharmacology,
R P Malone, and
M A Delaney, and
J F Luebbert, and
M A White, and
K A Biesecker, and
T B Cooper
October 1982,
The American journal of psychiatry,
