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OBJECTIVE To measure antibody titres to cardiac, nuclear, and streptococcal antigens in different groups of rheumatic fever (n = 60) and control subjects (n = 80) with the aim of identifying cross reactive antigens of potential laboratory diagnostic value. METHODS Enzyme linked immunosorbent assays (ELISA), immunocytochemical, and electrophoretic techniques were used to measure titres of antibodies to a variety of cardiac, nuclear, and streptococcal antigens in seven groups comprising patients with rheumatic fever and control subjects. RESULTS Increased concentrations of antibodies to several streptococcal and cardiac antigens, in addition to increased IgA and IgG levels, were noted in sera from patients with acute rheumatic fever and chronic rheumatic heart disease. Autoantibodies to nuclear antigens were evident in three rheumatic fever sera. CONCLUSIONS Although we were unable to identify any unique cross reactivity between cardiac and streptococcal antigens, these results demonstrate that there is an exaggerated humoral response to several cardiac, nuclear and streptococcal antigens in patients with rheumatic fever.
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
October 1985,
Medicina clinica,
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
January 1970,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale,
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
October 1970,
Journal of immunology (Baltimore, Md. : 1950),
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
December 1969,
Transplantation proceedings,
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
September 1987,
The Indian journal of medical research,
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
January 1966,
Bollettino della Societa italiana di cardiologia,
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
July 1988,
JPMA. The Journal of the Pakistan Medical Association,
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
January 1979,
Reviews of infectious diseases,
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
January 1969,
Godisen zbornik na Medicinskiot fakultet vo Skopje,
Q G Eichbaum, and
E J Hughes, and
J E Epstein, and
D W Beatty
February 1975,
Japanese circulation journal,
