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Epidermal Langerhans cells (LCs) isolated from individuals infected with human immunodeficiency virus (HIV-1) harbour HIV-1 proviral DNA and RNA, indicating productive infection by the virus in vivo. Furthermore, normal LCs can be infected in vitro by HIV and can present HIV antigens to helper T cells. Here, Giovanna Zambruno and colleagues discuss the possibility that LCs of genital mucosae are among the first targets of HIV infection following sexual contact, and can be involved both in the transmission of the infection to T cells and in T-cell priming to HIV antigens. In addition, epidermal LCs might acquire HIV infection from dermal T cells during transit from blood vessels through the dermis and may, in turn, represent a reservoir of the virus for continued T-cell infection.
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
January 1988,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
January 1993,
Advances in experimental medicine and biology,
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
December 1993,
Immunology letters,
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
June 1990,
Journal of the American Academy of Dermatology,
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
March 1994,
The British journal of dermatology,
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
November 1987,
Lancet (London, England),
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
August 2017,
Journal of dermatological science,
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
March 1990,
AIDS (London, England),
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
January 1988,
Advances in experimental medicine and biology,
G Zambruno, and
A Giannetti, and
U Bertazzoni, and
G Girolomoni
January 1991,
Research in virology,
