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The relationship between the irreversibly sickled cell (ISC) count and other haematological parameters has been investigated. Positive correlations occurred with the MCH, MCHC, and with two expressions of intracellular Hb S content. Since the ISC has a high MCHC, the positive correlations with MCHC and with factors derived from the MCHC may be difficult to evaluate. Negative correlations occurred with total haemoglobin and Hb F. The MCHC was found to affect the relationship between HbF and ISC count, a low MCHC being associated with, and probably determining, lower ISC counts at any level of Hb F. It is proposed that a low MCHC may inhibit ISC formation and the practical implications of this are discussed.
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
January 2000,
West African journal of medicine,
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
January 1982,
The American journal of pediatric hematology/oncology,
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
September 1985,
American journal of hematology,
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
February 1976,
Biochemical medicine,
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
January 1985,
Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia,
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
September 1977,
The Journal of laboratory and clinical medicine,
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
February 1984,
Blood,
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
February 2004,
Cellular and molecular biology (Noisy-le-Grand, France),
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
April 1984,
The Journal of laboratory and clinical medicine,
G R Serjeant, and
B E Serjeant, and
P Desai, and
K P Mason, and
A Sewell, and
J M England
January 1980,
The Journal of clinical investigation,
