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The study was undertaken to examine blood coagulative parameters in experimental orthotopic liver grafting. Plasma hemostatic parameters were studied in animals undergone successful and unsuccessful surgery. The preservation of a graft, anesthetization, and blood-substitute therapy were found to substantially affect the severity of hemostatic disorders. The liver-free period was characterized by changes in the fibrinolytic system and the activity of a plasma coagulation, by enhanced hypocoagulation, and thrombocytopenia. The findings suggest that timely correction of blood coagulative disorders is highly essential in orthotopic liver grafting. Prevention and prompt correction of hypocoagulation and thrombocytopenia are the most urgent.
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