Biomaterial Database

Liver alcohol dehydrogenase activity and ethanol levels during chronic ethanol intake in pregnant rats and their offspring. 1995

C Través, and L Camps, and D López-Tejero

Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.

The effects of chronic alcohol intake on the ethanol levels in body fluids (blood, amniotic fluid, and fetal intragastric content), hepatic alcohol dehydrogenase (ADH) activity, isoenzyme distribution, and hepatic zinc levels were studied in pregnant rats at term (19 and 21 days), in their offspring at fetal, perinatal, and weaned stages, and in adult virgin rats. Three experimental groups were studied: 1) the alcohol group received ethanol in drinking water (from 10% to 25% over 2 months), 2) the fibre diet group was undernourished on a hypocaloric diet, to assess the effects of malnutrition associated with chronic alcohol intake, and 3) the control group received no alcohol and normal diet. A gradient of increasing ethanol concentrations was found in fetal blood, amniotic fluid, and fetal intragastric contents with respect to maternal blood. A decrease in ADH activity was found in alcohol-consuming pregnant rats compared to controls. This was related neither to liver ADH isoenzyme distribution nor to changes in hepatic zinc levels. Chronic alcohol consumption in pregnant rats produced high ethanol accumulation in fetal fluids and changes in the liver ADH activity depending on the physiological situation (pregnancy, development, virgin state).

UI	MeSH Term	Description	Entries
D007527	Isoenzymes	Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.	Alloenzyme,Allozyme,Isoenzyme,Isozyme,Isozymes,Alloenzymes,Allozymes
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011270	Pregnancy, Animal	The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.	Animal Pregnancies,Animal Pregnancy,Pregnancies, Animal
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D004592	Electrophoresis, Starch Gel	Electrophoresis in which a starch gel (a mixture of amylose and amylopectin) is used as the diffusion medium.	Starch Gel Electrophoresis
D004734	Energy Metabolism	The chemical reactions involved in the production and utilization of various forms of energy in cells.	Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005260	Female		Females
D005753	Gastric Mucosa	Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.	Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland