-transparent.png){kind=logo}
The effect of vitamin A acetate on the urinary bladder carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was determined in male Wistar rats. Vitamin A acetate at the dose administered induced no changes in the urinary bladder or other organs when administered without the carcinogen. However, hypervitaminosis A inhibited keratinization and squamous metaplasia in bladder lesions induced by BBN, and the incidence of transitional cell carcinoma and papilloma of the urinary bladder was significantly reduced at a dose greater than 100 IU/g diet (P less than 0.02). The present experiment suggests that for the urinary bladder epithelium of rats hypervitaminosis A reduced susceptibility to the tumorigenicity of BBN.
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
August 1987,
Journal of the National Cancer Institute,
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
June 1994,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
January 2024,
Methods in molecular biology (Clifton, N.J.),
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
August 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
January 1984,
Journal of cancer research and clinical oncology,
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
February 1977,
Gan,
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
November 1996,
Carcinogenesis,
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
January 2014,
Chemotherapy,
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
December 1987,
Cancer research,
Y Miyata, and
H Tsuda, and
K Matayoshi-Miyasato, and
S Fukushima, and
G Murasaki, and
T Ogiso, and
N Ito
August 1969,
Gan,
