BIOMAT Database Logo BIOMAT Database Logo

Longitudinal analysis of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in rapidly progressing and nonprogressing HIV-1-infected subjects. 1993

M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Department of Infectious Diseases, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas.

Antibody response to conserved human immunodeficiency virus type 1 (HIV-1)IIIB gp160 epitopes was longitudinally examined in HIV-1-infected persons. Twelve hundred individuals were evaluated, and sequential sera from 25 rapidly progressing (RP) and 30 nonprogressing (NP) subjects collected over an average of 4 years were examined. Initial sera from the RP group contained greater reactivity to a gp120 epitope defined by peptide 503-528 than did sera from the NP group (P < .001). Reactivity declined with sequential sera for the RP group, paralleling disease progression. Conversely, antibody recognition to this site developed in 23% of the NP group with time. However, 60% of the NP group never developed a response to this epitope. This suggests sequential examination of antibody response to an epitope within the gp120 carboxyl-terminus may have prognostic significance. No association between antibodies directed against the gp160 epitopes and in vitro neutralizing activity against HIV-1IIIB was observed.

UI MeSH Term Description Entries
D008137 Longitudinal Studies Studies in which variables relating to an individual or group of individuals are assessed over a period of time. Bogalusa Heart Study,California Teachers Study,Framingham Heart Study,Jackson Heart Study,Longitudinal Survey,Tuskegee Syphilis Study,Bogalusa Heart Studies,California Teachers Studies,Framingham Heart Studies,Heart Studies, Bogalusa,Heart Studies, Framingham,Heart Studies, Jackson,Heart Study, Bogalusa,Heart Study, Framingham,Heart Study, Jackson,Jackson Heart Studies,Longitudinal Study,Longitudinal Surveys,Studies, Bogalusa Heart,Studies, California Teachers,Studies, Jackson Heart,Studies, Longitudinal,Study, Bogalusa Heart,Study, California Teachers,Study, Longitudinal,Survey, Longitudinal,Surveys, Longitudinal,Syphilis Studies, Tuskegee,Syphilis Study, Tuskegee,Teachers Studies, California,Teachers Study, California,Tuskegee Syphilis Studies
D008297 Male Males
D009500 Neutralization Tests The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50). Neutralization Test,Test, Neutralization,Tests, Neutralization
D011498 Protein Precursors Precursors, Protein
D005260 Female Females
D006679 HIV Seropositivity Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV). AIDS Seroconversion,AIDS Seropositivity,Anti-HIV Positivity,HIV Antibody Positivity,HIV Seroconversion,HTLV-III Seroconversion,HTLV-III Seropositivity,AIDS Seroconversions,AIDS Seropositivities,Anti HIV Positivity,Anti-HIV Positivities,Antibody Positivities, HIV,Antibody Positivity, HIV,HIV Antibody Positivities,HIV Seroconversions,HIV Seropositivities,HTLV III Seroconversion,HTLV III Seropositivity,HTLV-III Seroconversions,HTLV-III Seropositivities,Positivities, Anti-HIV,Positivities, HIV Antibody,Positivity, Anti-HIV,Positivity, HIV Antibody,Seroconversion, AIDS,Seroconversion, HIV,Seroconversion, HTLV-III,Seroconversions, AIDS,Seroconversions, HIV,Seroconversions, HTLV-III,Seropositivities, AIDS,Seropositivities, HIV,Seropositivities, HTLV-III,Seropositivity, AIDS,Seropositivity, HIV,Seropositivity, HTLV-III
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000939 Epitopes Sites on an antigen that interact with specific antibodies. Antigenic Determinant,Antigenic Determinants,Antigenic Specificity,Epitope,Determinant, Antigenic,Determinants, Antigenic,Specificity, Antigenic
D015331 Cohort Studies Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics. Birth Cohort Studies,Birth Cohort Study,Closed Cohort Studies,Cohort Analysis,Concurrent Studies,Historical Cohort Studies,Incidence Studies,Analysis, Cohort,Cohort Studies, Closed,Cohort Studies, Historical,Studies, Closed Cohort,Studies, Concurrent,Studies, Historical Cohort,Analyses, Cohort,Closed Cohort Study,Cohort Analyses,Cohort Studies, Birth,Cohort Study,Cohort Study, Birth,Cohort Study, Closed,Cohort Study, Historical,Concurrent Study,Historical Cohort Study,Incidence Study,Studies, Birth Cohort,Studies, Cohort,Studies, Incidence,Study, Birth Cohort,Study, Closed Cohort,Study, Cohort,Study, Concurrent,Study, Historical Cohort,Study, Incidence

Related Publications

M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Synthetic peptides define the fine specificity of the human immunodeficiency virus (HIV) gp160 humoral immune response in HIV type 1-infected chimpanzees.
February 1990, Journal of virology,
M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjects.
September 2013, Journal of virology,
M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Fine specificity of the humoral immune response to HIV-1 GP160 in HIV-1 infected individuals from Tanzania.
May 1992, Journal of medical virology,
M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Patterns of antibody reactivity to selected human immunodeficiency virus type 1 (HIV-1) gp160 epitopes infected individuals grouped according to CD4+ cell levels.
January 1991, Journal of clinical immunology,
M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Comparison of antibody reactivity to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in sera from HIV-1-infected individuals from Tanzania and from the United States.
January 1992, Journal of clinical microbiology,
M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Hemophilia and nonprogressing human immunodeficiency virus type 1 infection.
July 1997, Haemophilia : the official journal of the World Federation of Hemophilia,
M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Hemophilia and nonprogressing human immunodeficiency virus type 1 infection.
January 1997, Blood,
M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Ontogeny of the humoral immune response to human immunodeficiency virus type 1 in infants.
August 1993, The Journal of infectious diseases,
M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Low relative frequencies of CD26(+) CD4(+) cells in long-term nonprogressing human immunodeficiency virus type 1-infected subjects.
September 1998, Clinical and diagnostic laboratory immunology,
M T Wong, and R Q Warren, and S A Anderson, and M J Dolan, and C W Hendrix, and S P Blatt, and G P Melcher, and R N Boswell, and R C Kennedy
Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment.
November 2007, Memorias do Instituto Oswaldo Cruz,
Copied contents to your clipboard!