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This study was designed to evaluate the metabolic response to limitation of fat mobilization during severe exercise in man. To this end, we assessed the relationship between fat mobilization, lipid-ketone physiology, and exercise-induced elevations in the counter-regulatory hormones. Ten well trained athletes ran a 10-mile premeasured course in as short a time as possible during both a placebo and an experimental study. In the experimental study, fat mobilization was inhibited by the oral administration of 2 g of nicotinic acid. Blood samples for multiple substrate and hormonal assay were obtained 2 h before exercise, immediately before exercise, and immediately after exercise. In the experimental study, nicotinic acid effectively blocked the expected rise in plasma free fatty acid concentration observed in the placebo study. Although blunted, the exercise-induced rise in plasma ketone concentration persisted in spite of the reduced free fatty acid levels. The significance of the concommitant exagerated rise in glucagon and GH in stimulating ketogenesis is discussed. The inhibition of fat mobilization did not reduce the mean time required to run 10 miles. Since muscle uptake of free fatty acid is directly proportional to the plasma concentration of this substrate, our study suggests that the inability to mobilize fat does not prevent severe exercise for 70 min.
B Norris, and
D S Schade, and
R P Eaton
September 1967,
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B Norris, and
D S Schade, and
R P Eaton
December 1971,
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B Norris, and
D S Schade, and
R P Eaton
January 1972,
Recent advances in studies on cardiac structure and metabolism,
B Norris, and
D S Schade, and
R P Eaton
June 1970,
Acta physiologica Scandinavica,
B Norris, and
D S Schade, and
R P Eaton
May 1989,
Metabolism: clinical and experimental,
B Norris, and
D S Schade, and
R P Eaton
January 1973,
Endokrinologie,
B Norris, and
D S Schade, and
R P Eaton
January 1976,
Recent advances in studies on cardiac structure and metabolism,
B Norris, and
D S Schade, and
R P Eaton
March 1964,
Life sciences (1962),
B Norris, and
D S Schade, and
R P Eaton
March 2014,
Proceedings of the National Academy of Sciences of the United States of America,
B Norris, and
D S Schade, and
R P Eaton
June 1967,
Metabolism: clinical and experimental,
