-transparent.png){kind=logo}
2-Nitropropane (2-NP), a hepatocarcinogen in male Sprague-Dawley rats but not, under the same conditions, in male New Zealand White rabbits, induces characteristic base modifications in rat liver DNA and RNA including increases in 8-oxoguanine and the formation of 8-aminoguanine. We compared the levels of these modifications in the two animal species at 6, 18 and 42 h after a single i.p. treatment with 1.12 mmol/kg 2-NP. Significantly less nucleic acid base modifications were found to be produced in rabbit liver than in rat liver. Thus, the relative resistance of the rabbit to the hepatocarcinogenicity of 2-NP correlates with decreased levels of 2-NP-induced liver DNA and RNA base damage.
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
March 1993,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
September 1990,
Carcinogenesis,
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
December 1996,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
October 1989,
Cancer research,
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
August 1982,
Ecotoxicology and environmental safety,
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
April 2003,
Birth defects research. Part B, Developmental and reproductive toxicology,
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
July 2009,
Journal of applied toxicology : JAT,
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
January 2021,
PloS one,
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
December 1987,
Carcinogenesis,
E S Fiala, and
G Nie, and
R Sodum, and
C C Conaway, and
O S Sohn
September 2019,
Reproductive toxicology (Elmsford, N.Y.),
