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Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin. 1994
K Misterek, and
I Maszczynska, and
A Dorociak, and
S W Gumulka, and
D B Carr, and
S K Szyfelbein, and
A W Lipkowski
Department of Pharmacodynamics, Medical Academy, Warsaw, Poland.
Intrathecal injection of 0.25 micrograms of undecapeptide substance P antagonist (SPA) produced transient antinociception with a peak effect at 5 min. Increasing the SPA dose resulted in neurotoxicity. Intrathecal injection of the opioid peptide biphalin (BIP) produced antinociception for over 3 hrs without neurotoxicity. Co-administration of SPA (at subtoxic doses) increased BIP's antinociceptive effect. Naltrexone reversed analgesia due to BIP alone as well as after BIP+SPA.
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