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We studied samples containing deletions of the long arm of chromosome 11 (11q) from patients with hematologic malignancies by using cytogenetic and fluorescence in situ hybridization (FISH) techniques. Cytogenetic analysis of 28 patients and of a cell line showed that all deletions included band 11q23. FISH analysis demonstrated that the proximal part of 11q23, including NCAM, was deleted in 13 of 15 patients and the cell line. Recurring chromosomal losses in human tumors have been regarded as evidence that the affected regions contain tumor-suppressor genes. These results suggest that the putative tumor-suppressor gene is proximal to the MLL gene which is also located in 11q23.
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
September 1995,
Genes, chromosomes & cancer,
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
June 1993,
The Japanese journal of human genetics,
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
November 1994,
Blood,
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
August 2004,
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
May 1984,
Cancer genetics and cytogenetics,
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
June 2003,
Rinsho byori. The Japanese journal of clinical pathology,
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
February 2000,
Cancer genetics and cytogenetics,
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
December 2005,
Cancer genetics and cytogenetics,
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
November 1998,
Journal of pediatric surgery,
H Kobayashi, and
R Espinosa, and
A A Fernald, and
C Begy, and
M O Diaz, and
M M Le Beau, and
J D Rowley
February 2001,
Casopis lekaru ceskych,
